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Keck School of <br />Medicine of USC <br />Flavor and Menthol Tobacco Products and E-cigarettes <br />Since e-cigarettes have come to the Southern California market,the University of Southern California's expert <br />faculty and research staff at the Keck School of Medicine have focused on exploring the potential impacts of e- <br />cigarettes and flavored tobacco products on the general population as well as vulnerable populations, such as <br />adolescents and young adults. <br />E-cigarettes are drawing in new youth smokers who would have otherwise been unlikely to smoke <br />combustible cigarettes. <br />Two studies examining trends in tobacco use over time have shown that youth with no history of <br />cigarette use and who are otherwise unlikely to have smoked combustible cigarettes are initiating e- <br />cigarettes (1, 2). <br />Cartoon images and non-traditional flavors and unique flavor names are appealing to youth and increase <br />youth interest in e-cigarettes; most youth report initiation and continued use with flavored e-cigarettes <br />3-7).* <br />A study from Southern California youth reported that the most common reason for use of e-cigarettes <br />are the availability of e-cigarettes in a wide variety of flavors (i.e. fruit, dessert, mint, etc.) (7, 8). <br />E-cigarette companies actively market and re-post flavor-related information on social media at a much <br />higher rate than non-flavor related posts (9). <br />The availability of flavored e-cigarettes has been tied not only to initiation but also to continued use <br />among youth, and a majority of youth reported that they would no longer use e-cigarettes if flavors <br />were not available (6, 11).t <br />JUUL and other low profile products that resemble computer flash drivers thwart efforts to enforce <br />smoking policy by providing easy concealment from authorities (3). <br />A content analysis of customer reviews of 103 vape shops revealed that the most important attribute of <br />a shop was related to their flavor selection (10). <br />17.3%of California high school students reported being a current user of an electronic vapor product, <br />versus 13.2% national (12).t <br />There are clear health-related consequences of e-cigarette use among youth. <br />Youth who use e-cigarettes are 3 times as likely as those who have never used e-cigarettes to begin <br />smoking combustible cigarettes (13-19)*. <br />Youth who use e-cigarettes and subsequently begin smoking cigarettes follow a similar trajectory into <br />more frequent cigarette smoking as their peers who began smoking cigarettes without using e- <br />cigarettes first(1, 2). <br />A study among Southern California Hispanic young adults reported that using e-cigarettes increased the <br />likelihood of transitioning from a non-user to user of cigarettes or marijuana and was not associated <br />with smoking cessation (38). <br />Level of nicotine in e-cigarettes has been associated with higher frequency of subsequent cigarette <br />smoking (36). <br />Exposure to nicotine in e-cigarettes is addictive (14-19)*. <br />E-cigarettes can have adverse respiratory effects (20)*. <br />E-liquids contain many harmful chemicals (i.e. acetals, formaldehyde, cinnamaldehyde, diacetyl, <br />benzaldehyde, etc.)that are used to create the wide variety of flavors (21, 22).t <br />Research conducted outside of USC *Both USC and Outside Research Updated 5/22/2019